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Botanical Name |
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Panax ginseng C. A. Mey. |
English
Name |
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Ginseng, Asian ginseng, Asiatic ginseng, Chinese ginseng, Ginseng, Korean ginseng, Manchurian ginseng, Oriental ginseng, Red ginseng, White ginseng, |
Synonym(s) |
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Panax schinseng T. Nees, Panax schinseng T. Nees var. coraiensis T. Nees |
Family |
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Araliaceae |
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General Info
Description |
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A perennial herb growing 30-60 cm tall. Rootstock usually with 1- or 2-fascicled roots, fusiform or cylindric. Leaves 3-6, verticillate at apex of stem, palmately compound; petiole base without stipule or stipulelike appendages; leaflets 3-5, membranous, abaxially glabrous, adaxially sparsely setose (trichomes ca. 1 mm), base broadly cuneate, margin densely serrulate, apex long acuminate; central leaflet elliptic to oblong-elliptic, 8-12 × 3-5 cm; lateral leaflets ovate to rhombic-ovate, 2-4 × 1.5-3 cm. Inflorescence a solitary, terminal umbel 30-50-flowered; peduncle 15-30 cm, usually longer than petiole; pedicels 0.8-1.5 cm. Ovary 2-carpellate; styles 2, distinct. Fruit red, compressed-globose, 4-5 × 6-7 mm; seeds nephroid, white. |
Herb Effects |
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Adaptogen, alterative, carminative, demulcent, emetic, expectorant, stimulant and tonic (root); emetic and expectorant (leaves) |
Chemistry
Active Ingredients |
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Ascorbic acid, beta-carotene, beta-elemene, beta-sitosterol, choline, citric acid, fumaric acid, Ginsenoside Ro, ginsenoside Rb3, Ginsenoside Re, ginsenoside Rg2, ginsenoside Rh1, malic acid, oleanolic acid, panaxin, panaxydol, panaxynol, pantothenic acid, tartaric acid (root); Ginsenoside-Rb-1 (bud); ginsenoside Rb2, ginsenoside Rc, ginsenoside Rd, ginsenoside Re, ginsenoside Rg1 (flower); kaempferol, luteolin-7-glucoside (leaves) |
Chemistry
of Active Ingredients |
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Name |
CAS# |
IUPAC Name |
Formula |
Structure |
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Ascorbic acid |
Not Available |
2-(1,2-dihydroxyethy l)-4,5-dihydroxy-fur an-3-one |
C6H8O6 |
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Beta carotene |
7235-40-7 |
3,7,12,16-tetramethy l-1,18-bis(2,6,6-tri methyl-1-cyclohexeny l)-octadec
a-1,3,5, 7,9,11,13,15,17-nona ene |
C40H56 |
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Beta-elemene |
33880-83-0 |
1-ethenyl-1-methyl-2 ,4-diprop-1-en-2-yl- cyclohexane |
C15H24 |
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Choline |
67-48-1 |
2-hydroxyethyl-trime thyl-ammonium |
C5H14NO+ |
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Citric acid |
Not Available |
2-hydroxypropane-1,2 ,3-tricarboxylic acid |
C6H8O7 |
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Fumaric acid |
110-17-8 |
but-2-enedioic acid |
C4H4O4 |
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Ginsenoside Ro |
34367-04-9 |
(2S,3S,4S,5R,6R)-6-[ [(6aR,6bS,8aS,12aS,1 4bS)-4,4,6a,6b,11,11 ,14b-hepta
methyl-8 a-[(2S,3R,4S,5R,6R)- 3,4,5-trihydroxy-6-( hydroxymethyl)oxan-2 -y
l]oxycarbonyl-1, 2,3,4a,5,6,7,8,9,10, 12,12a,14,14a-tetrad ecahydropicen-
3-yl ]oxy]-3,4-dihydroxy- 5-[(2S,3R,4S,5R,6R)- 3,4,5-trihydroxy-6-( hydrox
ymethyl)oxan -2-yl]oxy-oxane-2-ca rboxylic acid |
C48H76O19 |
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Ginsenoside Rb3 |
Not Available |
(2S,3R,4S,5R,6R)-2-[ 2-[3-[(2R,3R,4S,5R,6 R)-4,5-dihydroxy-6-( hydroxymet
hyl)-3-[ (2S,3R,4S,5S,6R)-3,4 ,5-trihydroxy-6-(hyd roxymethyl)oxan-2-yl ]o
xy-oxan-2-yl]oxy -12-hydroxy-4,4,8,10 ,14-pentamethyl-2,3, 5,6,7,9,11,12,
13,1 5,16,17-dodecahydro- 1H-cyclopenta[a]phen anthren-17-yl]-6-met hyl-he
pt-5-en-2-yl ]oxy-6-[[(2R,3R,4S,5 S)-3,4,5-trihydroxyo xan-2-yl]oxymethyl
]oxane-3,4,5-triol |
C53H90O22 |
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Ginsenoside Re |
Not Available |
(2S,3R,4S,5R,6R)-2-[ (2S)-2-[(3S,5S,6S,8R ,9R,10R,12R,13R,14R, 17S)-6-[(2
R,3R,4S, 5R,6R)-4,5-dihydroxy -6-(hydroxymethyl)-3 -[(2S,3R,4R,5S,6S)-3 ,4
,5-trihydroxy-6- methyl-oxan-2-yl]oxy -oxan-2-yl]oxy-3,12- dihydroxy-4,4,
8,10 ,14-pentamethyl-2,3, 5,6,7,9,11,12,13,15, 16,17-dodecahydro-1H -cyclo
penta[a]phen anthren-17-yl]-6-met hyl-hept-5-en-2-yl]o xy-6-(hydroxymethy
l)oxane-3,4,5-triol |
C48H82O18 |
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Ginsenoside RG2 |
52286-74-5 |
(2S,3R,4R,5S,6S)-2-[ (2R,3R,4S,5R,6R)-2-[ [(6R,10R,12S,14R)-3, 12-dihydro
xy-17-[( E,2S)-2-hydroxy-6-me thyl-oct-5-en-2-yl]- 4,4,10,14-tetramethy l-
1,2,3,5,6,7,8,9, 11,12,13,15,16,17-te tradecahydrocyclopen ta[a]phenanthr
en-6 -yl]oxy]-4,5-dihydro xy-6-(hydroxymethyl) oxan-3-yl]oxy-6-meth yl-oxa
ne-3,4,5-tri ol |
C42H72O13 |
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Ginsenoside Rh1 |
63223-86-9 |
(2R,3R,4S,5R,6R)-2-[ [(3S,5S,6S,8R,10R,12 R,14R,17S)-3,12-dihy droxy-17-[
(2S)-2-h ydroxy-6-methyl-hept -5-en-2-yl]-4,4,8,10 ,14-pentamethyl-2,3, 5,
6,7,9,11,12,13,1 5,16,17-dodecahydro- 1H-cyclopenta[a]phen anthren-6-yl]o
xy]- 6-(hydroxymethyl)oxa ne-3,4,5-triol |
C36H62O9 |
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Malic acid |
Not Available |
2-hydroxybutanedioic acid |
C4H6O5 |
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Oleanolic acid |
508-02-1 |
10-hydroxy-2,2,6a,6b ,9,9,12a-heptamethyl -1,3,4,5,6,6a,7,8,8a ,10,11,12,
13,14b-t etradecahydropicene- 4a-carboxylic acid |
C30H48O3 |
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Panaxin |
11113-79-4 |
Not Available |
Not Available |
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Panaxydol |
72800-72-7 |
(3R)-8-[(2R,3S)-3-he ptyloxiran-2-yl]oct- 1-en-4,6-diyn-3-ol |
C17H24O2 |
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Panaxynol |
21852-80-2 |
(3R,9Z)-heptadeca-1, 9-dien-4,6-diyn-3-ol |
C17H24O |
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Pantothenic acid |
599-54-2 |
3-[(2,4-dihydroxy-3, 3-dimethyl-butanoyl) amino]propanoic acid |
C9H17NO5 |
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Tartaric acid |
526-83-0 |
2,3-dihydroxybutaned ioic acid |
C4H6O6 |
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Ginsenoside Rb1 |
Not Available |
(2R,3R,4S,5R,6R)-2-[ 2-[(3S,8R,10S,13R)-3 -[(2R,3R,4S,5R,6R)-4 ,5-dihydro
xy-6-(hy droxymethyl)-3-[(2R, 3R,4S,5R,6R)-3,4,5-t rihydroxy-6-(hydroxy me
thyl)oxan-2-yl]o xy-oxan-2-yl]oxy-12- hydroxy-4,4,8,10,14- pentamethyl-2,
3,5, 6,7,9,11,12,13,15,16 ,17-dodecahydro-1H-c yclopenta[a]phenanth ren-17
-yl]-6-methy l-hept-5-en-2-yl]oxy -6-[[(2R,3R,4S,5R,6R )-3,4,5-trihydroxy
-6-(hydroxymethyl)ox an-2-yl]oxymethyl]ox ane-3,4,5-triol |
C54H92O23 |
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Ginsenoside Rb2 |
75139-47-8 |
(2S,3R,5R,6R)-2-[(2S )-2-[(3S,5S,8R,9S,10 S,12R,13R,14R,17S)-3 -[(2R,3R,4
S,5R,6R) -4,5-dihydroxy-6-(hy droxymethyl)-3-[(2S, 3R,4S,5R,6R)-3,4,5-t ri
hydroxy-6-(hydro xymethyl)oxan-2-yl]o xy-oxan-2-yl]oxy-12- hydroxy-4,4,8,
10,1 4-pentamethyl-2,3,5, 6,7,9,11,12,13,15,16 ,17-dodecahydro-1H-c yclope
nta[a]phenan thren-17-yl]-6-methy l-hept-5-en-2-yl]oxy -6-[[(2R,3R,4S,5S)
-3,4,5-trihydroxyoxa n-2-yl]oxymethyl]oxa ne-3,4,5-triol |
C53H90O22 |
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Ginsenoside Rc |
Not Available |
(2R,3R,4S,5R,6S)-2-[ [(2R,3R,4S,5S)-3,4-d ihydroxy-5-(hydroxym ethyl)oxol
an-2-yl] oxymethyl]-6-[2-[(3S ,8R,10S,13R)-3-[(2R, 3R,4S,5R,6R)-4,5-dih yd
roxy-6-(hydroxym ethyl)-3-[(2S,3R,4S, 5R,6R)-3,4,5-trihydr oxy-6-(hydroxy
meth yl)oxan-2-yl]oxy-oxa n-2-yl]oxy-12-hydrox y-4,4,8,10,14-pentam ethyl-
2,3,5,6,7,9, 11,12,13,15,16,17-do decahydro-1H-cyclope nta[a]phenanthren-
17-yl]-6-methyl-hept -5-en-2-yl]oxy-oxane -3,4,5-triol |
C53H90O22 |
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Ginsenoside Rd |
52705-93-8 |
(2S,3R,4S,5R,6R)-2-[ (2S)-2-[(10S,12S,13S ,14R,17S)-3-[(2R,3R, 4S,5R,6R)-
4,5-dihy droxy-6-(hydroxymeth yl)-3-[(2S,3R,4S,5R, 6R)-3,4,5-trihydroxy -6
-(hydroxymethyl) oxan-2-yl]oxy-oxan-2 -yl]oxy-12-hydroxy-4 ,4,10,14-tetra
meth yl-1,2,3,5,6,7,8,9,1 1,12,13,15,16,17-tet radecahydrocyclopent a[a]ph
enanthren-17 -yl]-4,6-dimethyl-he pt-5-en-2-yl]oxy-6-( hydroxymethyl)oxan
e-3,4,5-triol |
C48H82O18 |
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Ginsenoside RG1 |
75139-45-6 |
2-[2-[3,12-dihydroxy -4,4,7,10,14-pentame thyl-6-[3,4,5-trihyd roxy-6-(hy
droxymet hyl)oxan-2-yl]oxy-1, 2,3,5,6,7,8,9,11,12, 13,15,16,17-tetradec ah
ydrocyclopenta[a ]phenanthren-17-yl]- 6-methyl-hept-5-en-2 -yl]oxy-6-(hyd
roxy methyl)oxane-3,4,5-t riol |
C42H72O14 |
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Kaempferol |
80714-53-0 |
3-[3-[4,5-dihydroxy- 6-(hydroxymethyl)-3- [3,4,5-trihydroxy-6- (hydroxyme
thyl)oxa n-2-yl]oxy-oxan-2-yl ]oxy-4,5-dihydroxy-6 -(hydroxymethyl)oxan -2
-yl]oxy-4,5-dihy droxy-2-(4-hydroxyph enyl)-chromen-7-one |
C33H40O21 |
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Luteolin-7-glucoside |
5373-11-5 |
2-(3,4-dihydroxyphen yl)-5-hydroxy-7-[(2S ,3R,4S,5R,6R)-3,4,5- trihydroxy
-6-(hydr oxymethyl)oxan-2-yl] oxy-chromen-4-one |
C21H20O11 |
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Pharmacology
Medicinal Use |
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The root both stimulates and relaxes the nervous system, encourages the secretion of hormones, improves stamina, lowers blood sugar and cholesterol levels and increases resistance to disease. It is used internally in the treatment of debility associated with old age or illness, lack of appetite, insomnia, stress, shock and chronic illness. The strong decoction of roots is given in large dosage orally for treating shortness of breath, listlessness, extremely weak pulse, extreme deficiency after a severe or prolonged illness, massive hemorrhage, excessive vomiting or diarrhea. The root decoction is also used alone or in combination with other drugs, in treating profuse sweating and cold limbs, lassitude, anorexia, feeling of fullness and stiffness in the upper abdomen, diarrhea, cough, asthenia, spontaneous sweating, thirst, diabetes, irritablility, insomnia, dreaminess, palpitation induced by fright, forgetfulness, listlessness, and lassitude and blood deficiency. This herb given with Yang tonics is used to treat impotence due to kidney deficiency and to enhance general immunity. |
Contraindication |
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1. Should not be prescribed for pregnant women, or for patients under the age of 40, or those with depression, acute anxiety or acute inflammatory disease. 2. Not to be prescribed in cases of Excess and Heat syndromes without Vital Qi Deficiency. 3. Not to be used with black hellebore, trogopterus dung, or honey locust. 4. Radish and tea should be avoided because they reduce ginseng’s efficiency. |
Reference |
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Jing-Nuan Wu. An Illustrated Chinese Materia Medica. P: 460-461, Oxford University Press, Inc.2005. |
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