Changsha Natureway Co., Ltd.

Giant Knotweed Extract

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cuspidatum sieb.et Zuec Part used: Rhizome Appearance: Orange or redish brown powder Test Method:HPLC Part of the Plant Used: Root & Rhizome of Polygonum cuspidatum Sieb. et Zucc. Extract Method:Alcohol Applicable field:Medicine Assay:10%--99% Active material: Resveratrol Molecular Formula :C14H12O3 Molecular Weight:228.24 Melting point: 253oC-255oC Solubility: soluble in diethyl ether, Chloroform, Etheyl alcohol, Acetone Packing: Double-deck plastic bag, pack with aluminium foil paper outside Shelf Life : 2 years under well Storage situation and stored away from direct sun light. What is the Giant Knotweed Extract? Giant knotweed is an east Asian species (Polygonum cuspidatum), belonging to the Polygonaceae family. Documented uses in traditional Chinese medicine date to the first century BC, and contemporary medical uses supported by clinical results include acute microbial infections or viral hepatitis, chemo- or radiation-induced leukocytopenia, atherosclerosis, and hyperlipidemia. Giant knotweed extract has exhibited antitussive, antihistaminic, hypotensive, vasodilating, cytotoxic, and antioxidant properties, among others. Giant knotweed extract is also a concentrated source of resveratrol, an antioxidant phenol produced in response to fungi. Resveratrol has also shown antimutagenic activity in bioassays conducted on bacteria in vitro. And, in a recent investigation conducted in vivo and in vitro, resveratrol displayed chemopreventive effects at three critical stages of carcinogenesis. Specifically, resveratrol was found to 1) induce phase II drug metabolizing enzymes; 2) mediate anti-inflammatory effects and inhibit cyclooxygenase and hydro-peroxidase (antipromotion); and 3) induce human promyelocytic leukemia cell diferentiation. Resveratrol was also found to inhibit the development of preneoplastic lesions in vitro and tumorigenesis in vivo. Very recently, it was reported that Giant knotweed extract is one of the best active-oxygen scavengers for the prevention of skin aging induced by UV-irradiation and free radical. Experiments conducted in vivo indicate that resveratrol is a potent vasodilator and inhibitor of platelet aggregation. Recent work in dogs and humans indicate that other concentrated sources of resveratrol eliminate cyclic blood-flow reductions caused by platelet-mediated thrombosis.

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