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Harpagophytum procumbens (Burch.) DC. ex Meisn.


Botanical Name	:	Harpagophytum procumbens (Burch.) DC. ex Meisn.
English Name	:	Devil's Claw, Grapple plant, Wood spider
Synonym(s)	:	Uncaria procumbens Burch.
Family	:	Pedaliaceae

General Info

Description

A weedy perennial with a central taproot and secondary root tubers (storage roots) branching off horizontally. The roots are found up to 2m deep and the secondary storage roots are up to 25cm long and 6cm thick . Flowers are yellow-violet. Fruits are studded with hooks.

Herb Effects

Allergenic, analgesic, antiarrhythmic, antiarthritic, antiinflammatory, antipyretic, antirheumatic, choleretic, depurative, digestive, diuretic, hypocholesterolemic, hypotensive, laxative, secretagogue, sedative, tonic, uricolytic, uterocontractant.

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Harpagophytum procumbens

Chemistry

Active Ingredients

Acetoside, chlorogenic acid, cinnamic acid, fisetin, harpagide, harpagoside, kaempferol, luteolin, oleanolic acid, raffinose (root)

Chemistry of Active Ingredients

Name

CAS#

IUPAC Name

Formula

Structure

Chlorogenic acid

327-97-9

3-[3-(3,4-dihydroxyp
henyl)prop-2-enoylox
y]-1,4,5-trihydroxy-
cyclohexan e-1-carb
oxylic acid

C₁₆H₁₈O₉

Cinnamic acid

63938-16-9

3-phenylprop-2-enoic
acid

C₉H₈O₂

Fisetin

Not Available

2-(3,4-dihydroxyphen
yl)-3,4-dihydroxy-ch
romen-7-one

C₁₅H₁₀O₆

Harpagide

6926-08-5

(1S,5S,6R,7S,9R)-7-m
ethyl-5-[(2S,3R,4S,5
R,6R)-3,4,5-trihydro
xy-6-(hydr oxymethy
l)oxan-2-yl]oxy-4-ox
abicyclo[4.3.0]non-2
-ene-1,7,9-triol

C₁₅H₂₄O₁₀

Harpagoside

Not Available

[(1S,5S,6R,9R)-1,9-d
ihydroxy-7-methyl-5-
[(2S,3R,4S,5S,6R)-3,
4,5-trihyd roxy-6-(
hydroxymethyl)oxan-2
-yl]oxy-4-oxabicyclo
[4.3.0]non-2-en-7-yl
]
(E)-3-phenylprop-2
-enoate

C₂₄H₃₀O₁₁

Kaempferol

80714-53-0

3-[3-[4,5-dihydroxy-
6-(hydroxymethyl)-3-
[3,4,5-trihydroxy-6-
(hydroxyme thyl)oxa
n-2-yl]oxy-oxan-2-yl
]oxy-4,5-dihydroxy-6
-(hydroxymethyl)oxan
-2 -yl]oxy-4,5-dihy
droxy-2-(4-hydroxyph
enyl)-chromen-7-one

C₃₃H₄₀O₂₁

Luteolin

Not Available

2-(3,4-dihydroxyphen
yl)-4,5-dihydroxy-ch
romen-7-one

C₁₅H₁₀O₆

Oleanolic acid

508-02-1

10-hydroxy-2,2,6a,6b
,9,9,12a-heptamethyl
-1,3,4,5,6,6a,7,8,8a
,10,11,12,
13,14b-tetradecahydr
opicene-4a-carboxyli
c acid

C₃₀H₄₈O₃

Raffinose

Not Available

(2S,3R,4S,5S,6R)-2-[
[(2R,3R,4S,5R,6R)-6-
[(2S,3S,4R,5R)-3,4-d
ihydroxy-2 ,5-bis(h
ydroxymethyl)oxolan-
2-yl]oxy-3,4,5-trihy
droxy-oxan-2-yl]meth
ox y]-6-(hydroxymet
hyl)oxane-3,4,5-trio
l

C₁₈H₃₂O₁₆

Pharmacology

Medicinal Use

For treating diseases of the liver, kidneys, gallbladder and bladder, arthritis, rheumatism, improve the vitality of the joints, diabetes, hardening of the arteries, lumbago, gastrointestinal disturbances, menstrual difficulties, neuralgia, headache, heartburn and gout

Contraindication

Promotes the secretion of stomach acid, leading to difficulties in those with peptic ulcers, gastritis or excess stomach acid. Contraindicated for individuals with gallstones

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